Tuesday, July 2, 2013

I'm new here...

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New (or returning) members post here to announce your arrival and be greeted by our wonderful community. Also, if you're going away on leave, post here and we'll say our goodbyes.

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Hello there.
I'm new here and looking to role play asap. *bows*

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Loki_Laufeyson
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Inactivation of taste genes causes male sterility

July 1, 2013 ? Scientists from the Monell Center report the surprising finding that two proteins involved in oral taste detection also play a crucial role in sperm development.

"This paper highlights a connection between the taste system and male reproduction," said lead author Bedrich Mosinger, MD, PhD, a molecular biologist at Monell. "It is one more demonstration that components of the taste system also play important roles in other organ systems."

While breeding mice for taste-related studies, the researchers discovered that they were unable to produce offspring that were simultaneously missing two taste-signaling proteins.

As reported online in advance of print in the Proceedings of the National Academy of Sciences, the critical proteins were TAS1R3, a component of both the sweet and umami (amino acid) taste receptors, and GNAT3, a molecule needed to convert the oral taste receptor signal into a nerve cell response.

Breeding experiments determined that fertility was affected only in males. Both taste proteins had previously been found in testes and sperm, but until now, their function there was unknown.

In order to explore the reproductive function of the two proteins, the research team engineered mice that were missing genes for the mouse versions of TAS1R3 and GNAT3 but expressed the human form of the TAS1R3 receptor. These mice were fertile.

However, when the human TAS1R3 receptor was blocked in the engineered mice by adding the drug clofibrate to the rodents' diet, thus leaving the mice without any functional TAS1R3 or GNAT3 proteins, the males became sterile due to malformed and fewer sperm. The sterility was quickly reversed after clofibrate was removed from the diet.

Clofibrate belongs to a class of drugs called fibrates that frequently are prescribed to treat lipid disorders such as high blood cholesterol or triglycerides. Previous studies from the Monell team had revealed that it is a potent inhibitor of the human, but not mouse, TAS1R3 receptor.

Noting the common use of fibrates in modern medicine and also the widespread use in modern agriculture of the structurally-related phenoxy-herbicides, which also block the human TAS1R3 receptor, Mosinger speculates that these compounds could be negatively affecting human fertility, an increasing problem worldwide.

He in turn notes positive implications related to the research. "If our pharmacological findings are indeed related to the global increase in the incidence of male infertility, we now have knowledge to help us devise treatments to reduce or reverse the effects of fibrates and phenoxy-compounds on sperm production and quality. This knowledge could further be used to design a male non-hormonal contraceptive."

Previous work from Monell and other groups has shown that some taste genes can be found in other parts of the body, including stomach, intestines, pancreas, lungs, and brain, where they are increasingly thought to have important physiological functions.

"Like much good science, our current findings pose more questions than answers," comments Monell molecular neurobiologist Robert Margolskee, MD, PhD, also an author on the paper. "We now need to identify the pathways and mechanisms in testes that utilize these taste genes so we can understand how their loss leads to infertility."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/gB5qVs1hDYI/130701151447.htm

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Anthony Albanese appointed communications minister - mUmBRELLA

Anthony Albanese appointed communications minister     AlboDeputy Prime Minister Anthony Albanese has been appointed Minister for Broadband, Communications and the Digital Economy.

In a ministerial reshuffle announced this morning it was confirmed that Albanese he would replace Stephen Conroy who resigned last week following the leadership spill.

Albanese will also retain the?portfolios of transport and infrastructure.

According to the Australian Financial Review Albanese has been tasked by Kevin Rudd with prosecuting the case for Labor?s NBN policy.

July 1st, 2013 at 10:22 am

Source: http://mumbrella.com.au/albanese-appointed-communications-minister-164762

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Monday, July 1, 2013

Native Americans

James S. Robbins urges today?s Americans to ?recognize, honor, and carry forward the grand experiment of the first new nation.?

By Michael Taube / July 1, 2013

Native Americans: Patriotism, Exceptionalism, and the New American Identity, by James S. Robbins, Encounter Books, 250 pages

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The word ?American? evokes certain emotions.

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For some individuals, groups, and countries, it provokes a fiercely negative reaction, based on a perceived role of the United States in world affairs. Others will react more positively because of the country?s legacy of liberty and freedom.

What about Americans themselves in the 21st century? Like many non-Americans, their feelings of pride and admiration obviously range across a spectrum. But as the calendar inches closer to Independence Day, the desire to measure American values, beliefs, and patriotism takes on even greater importance.

James S. Robbins offers a passionate response to this critical call. Robbins is an author, deputy editor of Rare, member of USA Today?s board of contributors, and former senior editorial writer for foreign affairs at The Washington Times. In his powerful new book, Native Americans: Patriotism, Exceptionalism, and the New American Identity, he breaks down the American experience into various categories: citizen, identity, spirit, ideal, dream, values, and so on.

In clear, crisp language, using sharp analytical skills, Robbins treats readers to a scintillating history of American exceptionalism ? and what he sees as a desirable path for America?s future.

Robbins?s term ?native American? shouldn?t be confused with the more commonly used ?Native American.? What Robbins is referring to is the fact that he is ?indigenous to the North American continent,? doesn?t consider ?himself a hyphenated American ... except maybe suburban-American,? and believes his ?Americanism needs no prefix or suffix.?

While he recognizes that many of his fellow Americans have pride in the nation, he laments that there are some Americans today who are ?embarrassed for and ashamed of their fellow citizens.?

Why so? Robbins sees American identity as coming under siege from two directions: ?globalists seeking to dilute it, and multiculturalists trying to carve it up.? While Robbins accepts and appreciates the free-market perspective that globalization ?is the Americanizing of the world,? he objects to the globalist notion that ?the American nation is fading and becoming increasingly irrelevant.?

At the same time, Robbins says, multiculturalists see the term ?American? being ?defined by otherness, by being part of something apart from the whole, ex uno plures.?

To counter both perspectives, Robbins sets out to describe the beauty and boldness of American history, ideals, and values. For instance, the American frontier is depicted as ?a practical source of liberty.? Many of the early settlers perceived that ?America had a higher purpose? as a ?Zionist experiment.? The American Century ?was driven by both realist and idealist forces,? as the US ?was committed to defending the free world against the menace of international communism.?
For Robbins: ?Freedom is a defining aspect of the American character.? The origins of American-style freedom follow various trains of thought, including ancient Greek philosophers, John Calvin, and Magna Carta. America?s Founding Fathers, including George Washington, John Adams, and Thomas Jefferson, cherished freedom as much as they did justice and democracy.

Long story short, the American Revolution ?was not the birth of freedom in this country, but the defense of freedoms that had already been established.?
Another vital component of the American experience is patriotism. Conservatives use the word as a defense of the country?s founding principles, while liberals prefer to use it as a source of radical change and to ?promote social justice.?

A 2010 USA Today/Gallup poll revealed a significant left-right patriotism gap in American society. In Robbins?s view, conservatives ?did not appropriate the ideal of American patriotism,? whereas the political left ?abandoned patriotism sometime in the 1960s and never came back.???

Alas, there is much work still to be done. Robbins believes the ?stewardship of the country and, more importantly, of the ideal? requires future generations ?to recognize, honor, and carry forward the grand experiment of the first new nation.??

This will keep the spirit alive and well in the hearts and minds of all ?native Americans.? In turn, it will help ensure that America always remains the Beautiful.

Michael Taube is a columnist for The Washington Times, and a former speechwriter for Canadian Prime Minister Stephen Harper.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/CtqnMlOCxag/Native-Americans

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Absurd Stock Photos Made The First Silicon Alley Billionaire

Absurd Stock Photos Made The First Silicon Alley Billionaire

Photos of garbage or (fully clothed) people posing with fruit are big business. Stock photo sites, which provide images for news organizations, blogs, corporate campaigns and all manner of low-budget advertising, have been growing for years. And Shutterstock, founded in 2003 by Jonathan Oringer, has expanded from hosting 30,000 of Oringer's own photos to distributing about 28 million licensed photos/illustrations/videos. And all those cats riding merry-go-rounds have made Oringer a billionaire.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/rP9SJs0zpvM/absurd-stock-photos-made-the-first-silicon-alley-billio-625382145

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Arkansas Football Countdown Day 63: R.J. Morris

R.J. Morris is a player easy to root for because he's like us, living out a childhood dream.

Only nine weeks from today the crew from College Gameday will be prepping us for the first Saturday of college football, but in the interim, get to know redshirt freshman R.J. Morris.

Morris is an offensive lineman who hails from Naperville, IL, and is one of those players who makes himself easy to root for. Like most of us, he grew up a Razorback fan but instead of remaining a just a fan, he headed to join the team as a preferred walk-on.

He stands at 6-foot-4, 312-pound and played guard and tackle in high school, and mind you, Bret Bielema loves these kids too because he was once a walk-on out of high school as well.

Now while most of us never had the opportunity to accept a preferred walk-on offer, I have respect for anyone in his shoes--at any level-- who pays his own way through school while experiencing the pressures of such a demanding extracurricular activity.

If you can handle the Mississippi State-esque cowbells midway through this video for a few minutes, here are some high school highlights:

-----

A native of Arkansas now calling the Hogs from yonder in Georgia, you can follow Graham on Twitter @grahamreaves or read his blog, On My Mind In Georgia.

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Source: http://www.arkansasexpats.com/2013/6/29/4477122/arkansas-football-countdown-day-63-r-j-morris

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Bubble tea | Food and Beverage

Boba milk tea, also known as pearl milk tea or PMT, is a Taiwanese tea-based drink invented in tea shops in Taichung, Taiwan, during the 1980s. Most bubble tea recipes contain a tea base mixed with fruit or milk. Ice-blended versions are usually mixed with fruit or syrup, resulting in a slushy consistency. Most bubble teas come with small chewy tapioca balls, commonly called ?pearls? or ?boba? .

There are many variants of the drinks, and many kinds of types are used and ingredients added. The most popular bubble drinks are bubble milk tea with tapioca and bubble milk green tea with tapioca.

Source: http://heromobilecafe.com/bubble-tea

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