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Wednesday, March 6, 2013
Now You Can Get Your Favorite Mountain 3D Printed
Tuesday, March 5, 2013
Zedd Preps 'Proper Show' For Solo Tour Following Lady Gaga Cancellation
'I want to play really, really big venues,' Woodies-nominated 'Clarity' singer tells MTV News.
By Jocelyn Vena, with reporting by Sam Hendrick
Zedd
Photo: MTV News
Source: http://www.mtv.com/news/articles/1703009/zedd-tour-plans.jhtml
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Monday, March 4, 2013
Family brings down sinkhole house in search for brother - Herald.ie
MORE than half of the Florida home perched over a huge sinkhole that swallowed a man three days ago has been razed.
'; document.write(s); return; } window.google_adnum = window.google_adnum || null; google_ad_client = "ca-pub-9024837700129787"; google_ad_output = "js"; google_ad_type = "text"; google_ad_channel = '9868211012,8251877010'; google_max_num_ads = '2'; google_skip = window.google_adnum; /* insert this snippet for each ad call */Jeremy Bush (35) tried to save his brother, Jeff, when the earth opened up and swallowed him Thursday night. Yesterday morning, Bush and relatives prayed with a pastor as the home ? where he lived with his girlfriend, Rachel Wicker; their daughter, Hannah (2) ? was demolished.
Early yesterday morning, before the demolition began, Bush knelt and prayed at the mailbox in front of the home, owned by Rachel's grandfather, since the 1970s.
?
collapse
By yesterday afternoon only a few walls of the home remained and a Bible, family photos, a jewellery box and a pink teddy were among the items saved.
Hillsborough County Administrator Mike Merrill said the remaining walls of the home would be knocked down today and then crews would turn to clearing the debris as much as possible to allow officials and engineers to see the sinkhole.
Officials also will determine what will happen to the two homes on either side of the now-demolished house.
Experts say the sinkhole has "compromised" the structural integrity of these homes, but it's unclear whether steps can be taken to save them.
Several generations of family members lived in the home at the time of the ground collapse, including Jeff Bush, the man now presumed dead.
Jeremy Bush tried to save his brother by jumping in the hole.
He had to be pulled out of the still-shifting hole by a Hillsborough County Sheriff's Deputy.
"I've never seen anything move so fast and do so much destruction," Deputy Douglas Duvall said.
The search for Jeff Bush (37) was called off on Saturday.
He was in his bedroom on Thursday night in Seffner ? a suburb of in Tampa ? when the ground opened and took him and everything in his room.
hnews@herald.ie
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'; if (google_ads[0].bidtype == "CPC") { google_adnum = google_adnum + google_ads.length; } s += 'Source: http://www.herald.ie/news/family-brings-down-sinkhole-house-in-search-for-brother-29107457.html
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Study of tenofovir vaginal gel shows daily dosing ineffective due to lack of adherence
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Public release date: 4-Mar-2013[ | E-mail |
Share ] Contact: Annette Larkin
alarkin@conrad.org
703-772-6427
CONRAD
Previous study suggests coital dosing may be preferable and effective
ARLINGTON, VIRGINIA (12:15 EST MARCH 4, 2013) Researchers with the Microbicide Trials Network (MTN) today announced results of the Vaginal and Oral Interventions to Control the Epidemic (VOICE) study at the Conference for Retroviruses and Opportunistic Infections (CROI) in Atlanta, Georgia. The VOICE study tested oral and vaginal antiretroviral-based approaches as HIV prevention methods in 5,029 women in South Africa, Uganda, and Zimbabwe. Funded by the U.S. National Institutes of Health and managed by the MTN, the VOICE study was a major undertaking, which has provided important data regarding drug safety, effectiveness, acceptability and adherence.
"The principal investigators of the study, Drs. Jeanne Marazzo and Zvavahera Mike Chirenje, and the entire VOICE team have done an outstanding job," said CONRAD Executive Director Gustavo Doncel, M.D., Ph.D.
VOICE launched in September 2009 as a Phase IIB safety and effectiveness study to compare 3 different once-daily HIV prevention strategies: 1) a pill of combination emtricitabine and tenofovir (Truvada), 2) a pill containing only tenofovir (Viread), and 3) tenofovir 1% vaginal gel. Study participants received ongoing HIV risk-reduction counseling, condoms, and diagnosis and treatment of sexually transmitted infections throughout the trial. They were tested monthly for HIV and quarterly for drug levels.
In an evaluation of plasma samples in a subset of the women, drug was detected on average in 28% of participants taking oral tenofovir, 29% of participants taking oral Truvada, and 23% of participants in the vaginal gel study arm. Unfortunately, due to the low adherence, none of the products were deemed effective in reducing HIV acquisition in this particular trial. The estimates of effectiveness for both oral tenofovir and Truvada were less than zero. The study showed a 14.7% reduction of HIV infection in the tenofovir gel arm, when compared to placebo gel. This level of protection, however, was not statistically significant.
Some of the previous studies using the same antiretrovirals in tablet or gel form for HIV prevention showed effectiveness. In particular, CAPRISA 004, a study completed in 2010 using the same tenofovir vaginal gel used in the VOICE trial, showed an average of a 39% reduction in HIV infections and a 54% reduction in women who used it at least 80% of the time. Additionally, tenofovir gel reduced the risk of herpes genital infections by 51%. The dosing regimen was different than the daily dosing used in the VOICE study women in CAPRISA 004 were required to insert 1 dose before sex and 1 dose after sex, not to exceed 2 doses in 24 hours (a regimen dubbed BAT24). CAPRISA 004 was the first trial to show that a topical product containing tenofovir could reduce HIV infection and suggests that a dosing method that requires women to use the product around the time of sex, versus daily dosing, may be preferable to women.
To that end, FACTS 001, a study sponsored by CONRAD, funded by USAID, the Bill & Melinda Gates Foundation and the South African government, and co-chaired by the South African scientists, Drs. Helen Rees and Glenda Gray, is currently being conducted at 9 sites in South Africa. The trial replicates the dosing regimen used in CAPRISA 004 (i.e., BAT 24). FACTS 001 is using a variety of methods to collect information about gel use, condom use, and sexual behavior in order to measure adherence. The study has enrolled close to 1,900 participants and is expected to be complete at the end of 2014. FACTS 001 is an important study as it is designed to confirm the results obtained in CAPRISA 004 and contribute to the approval of tenofovir gel as a pericoital method for prevention of HIV infection in women.
The VOICE study also found that single women under 25 were the least likely to use the product and the most likely to acquire HIV. "The VOICE results highlight the gravity of the epidemic, especially in young, unmarried women, and the importance of developing products that appeal to them. At CONRAD, we remain committed to designing HIV prevention products based on innovation and sound product development strategies," said Dr. Doncel.
"The results of the CAPRISA 004 and VOICE trials illustrate that there are some women who may only want to use a product when they know they are having sex and the FACTS 001 study plays a very important role in testing that hypothesis. We need more information on the type of products that women who are at the highest risk level want and will use," said Dr. Jill Schwartz, CONRAD's Medical Director.
###
CONRAD, who has a royalty-free license to tenofovir gel from Gilead Sciences, manufactured and supplied the gel for these trials. CONRAD also holds the public sector licensing rights in developing countries for the prevention of genital herpes, a common sexually transmitted infection, through the use of tenofovir gel.
CONRAD was established in 1986 and is a Division of the Department of Obstetrics and Gynecology at Eastern Virginia Medical School (EVMS) in Norfolk, VA, where it has laboratories and a clinical research center. Thanks to our funders, which include the U.S. Agency for International Development and the Bill and Melinda Gates Foundation, CONRAD is a leader in researching and developing new contraceptive options and products to prevent HIV and STIs. The main office is located in Arlington, VA and we collaborate with academic and research institutions around the world.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 4-Mar-2013[ | E-mail |
Share ] Contact: Annette Larkin
alarkin@conrad.org
703-772-6427
CONRAD
Previous study suggests coital dosing may be preferable and effective
ARLINGTON, VIRGINIA (12:15 EST MARCH 4, 2013) Researchers with the Microbicide Trials Network (MTN) today announced results of the Vaginal and Oral Interventions to Control the Epidemic (VOICE) study at the Conference for Retroviruses and Opportunistic Infections (CROI) in Atlanta, Georgia. The VOICE study tested oral and vaginal antiretroviral-based approaches as HIV prevention methods in 5,029 women in South Africa, Uganda, and Zimbabwe. Funded by the U.S. National Institutes of Health and managed by the MTN, the VOICE study was a major undertaking, which has provided important data regarding drug safety, effectiveness, acceptability and adherence.
"The principal investigators of the study, Drs. Jeanne Marazzo and Zvavahera Mike Chirenje, and the entire VOICE team have done an outstanding job," said CONRAD Executive Director Gustavo Doncel, M.D., Ph.D.
VOICE launched in September 2009 as a Phase IIB safety and effectiveness study to compare 3 different once-daily HIV prevention strategies: 1) a pill of combination emtricitabine and tenofovir (Truvada), 2) a pill containing only tenofovir (Viread), and 3) tenofovir 1% vaginal gel. Study participants received ongoing HIV risk-reduction counseling, condoms, and diagnosis and treatment of sexually transmitted infections throughout the trial. They were tested monthly for HIV and quarterly for drug levels.
In an evaluation of plasma samples in a subset of the women, drug was detected on average in 28% of participants taking oral tenofovir, 29% of participants taking oral Truvada, and 23% of participants in the vaginal gel study arm. Unfortunately, due to the low adherence, none of the products were deemed effective in reducing HIV acquisition in this particular trial. The estimates of effectiveness for both oral tenofovir and Truvada were less than zero. The study showed a 14.7% reduction of HIV infection in the tenofovir gel arm, when compared to placebo gel. This level of protection, however, was not statistically significant.
Some of the previous studies using the same antiretrovirals in tablet or gel form for HIV prevention showed effectiveness. In particular, CAPRISA 004, a study completed in 2010 using the same tenofovir vaginal gel used in the VOICE trial, showed an average of a 39% reduction in HIV infections and a 54% reduction in women who used it at least 80% of the time. Additionally, tenofovir gel reduced the risk of herpes genital infections by 51%. The dosing regimen was different than the daily dosing used in the VOICE study women in CAPRISA 004 were required to insert 1 dose before sex and 1 dose after sex, not to exceed 2 doses in 24 hours (a regimen dubbed BAT24). CAPRISA 004 was the first trial to show that a topical product containing tenofovir could reduce HIV infection and suggests that a dosing method that requires women to use the product around the time of sex, versus daily dosing, may be preferable to women.
To that end, FACTS 001, a study sponsored by CONRAD, funded by USAID, the Bill & Melinda Gates Foundation and the South African government, and co-chaired by the South African scientists, Drs. Helen Rees and Glenda Gray, is currently being conducted at 9 sites in South Africa. The trial replicates the dosing regimen used in CAPRISA 004 (i.e., BAT 24). FACTS 001 is using a variety of methods to collect information about gel use, condom use, and sexual behavior in order to measure adherence. The study has enrolled close to 1,900 participants and is expected to be complete at the end of 2014. FACTS 001 is an important study as it is designed to confirm the results obtained in CAPRISA 004 and contribute to the approval of tenofovir gel as a pericoital method for prevention of HIV infection in women.
The VOICE study also found that single women under 25 were the least likely to use the product and the most likely to acquire HIV. "The VOICE results highlight the gravity of the epidemic, especially in young, unmarried women, and the importance of developing products that appeal to them. At CONRAD, we remain committed to designing HIV prevention products based on innovation and sound product development strategies," said Dr. Doncel.
"The results of the CAPRISA 004 and VOICE trials illustrate that there are some women who may only want to use a product when they know they are having sex and the FACTS 001 study plays a very important role in testing that hypothesis. We need more information on the type of products that women who are at the highest risk level want and will use," said Dr. Jill Schwartz, CONRAD's Medical Director.
###
CONRAD, who has a royalty-free license to tenofovir gel from Gilead Sciences, manufactured and supplied the gel for these trials. CONRAD also holds the public sector licensing rights in developing countries for the prevention of genital herpes, a common sexually transmitted infection, through the use of tenofovir gel.
CONRAD was established in 1986 and is a Division of the Department of Obstetrics and Gynecology at Eastern Virginia Medical School (EVMS) in Norfolk, VA, where it has laboratories and a clinical research center. Thanks to our funders, which include the U.S. Agency for International Development and the Bill and Melinda Gates Foundation, CONRAD is a leader in researching and developing new contraceptive options and products to prevent HIV and STIs. The main office is located in Arlington, VA and we collaborate with academic and research institutions around the world.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-03/c-sot030413.php
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Sunday, March 3, 2013
Kerry says US releasing millions in aid to Egypt
U.S. Secretary of State John Kerry, left, shakes hands with Egyptian President Mohamed Morsi at the Presidential Palace in Cairo, Egypt on Sunday, March 3, 2013. U.S. Secretary of State John Kerry met with Egypt's president Sunday, wrapping up a visit to the deeply divided country with an appeal for unity and reform. The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest. (AP Photo/Jacquelyn Martin, Pool)
U.S. Secretary of State John Kerry, left, shakes hands with Egyptian President Mohamed Morsi at the Presidential Palace in Cairo, Egypt on Sunday, March 3, 2013. U.S. Secretary of State John Kerry met with Egypt's president Sunday, wrapping up a visit to the deeply divided country with an appeal for unity and reform. The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest. (AP Photo/Jacquelyn Martin, Pool)
U.S. Secretary of State John Kerry waves goodbye as he leaves Cairo, Egypt en route to Riyadh, Saudi Arabia on Sunday, March 3, 2013. Kerry met with Egypt's president Sunday, wrapping up a visit to the deeply divided country with an appeal for unity and reform. The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest. (AP Photo/Jacquelyn Martin, Pool)
Egyptian Foreign Minister Mohammed Kamel Amr, left, U.S. Secretary of State John Kerry, center, and Egyptian President Mohamed Morsi take their seats at the starts of their meeting at the Presidential Palace in Cairo, Egypt on Sunday, March 3, 2013. Kerry met with Egypt's president Sunday, wrapping up a visit to the deeply divided country with an appeal for unity and reform. The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest. (AP Photo/Jacquelyn Martin, Pool)
U.S. Secretary of State John Kerry, left, meets with Egyptian President Mohamed Morsi at the Presidential Palace in Cairo, Egypt on Sunday, March 3, 2013. Kerry met with Egypt's president Sunday, wrapping up a visit to the deeply divided country with an appeal for unity and reform. The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest. (AP Photo/Jacquelyn Martin, Pool)
CAIRO (AP) ? U.S. Secretary of State John Kerry on Sunday rewarded Egypt for President Mohammed Morsi's pledges of political and economic reforms by releasing $250 million in American aid to support the country's "future as a democracy."
Yet Kerry also served notice that the Obama administration will keep close watch on how Morsi, who came to power in June as Egypt's first freely elected president, honors his commitment.
"The path to that future has clearly been difficult and much work remains," Kerry said in a statement after wrapping up two days of meetings in Egypt, a deeply divided country in the wake of the revolution that ousted longtime President Hosni Mubarak.
Egypt is trying to meet conditions to close on a $4.8 billion loan package from the International Monetary Fund. An agreement would unlock more of the $1 billion in U.S. assistance promised by President Barack Obama last year and set to begin flowing with Kerry's announcement.
"The United States can and wants to do more," Kerry said. "Reaching an agreement with the IMF will require further effort on the part of the Egyptian government and broad support for reform by all Egyptians. When Egypt takes the difficult steps to strengthen its economy and build political unity and justice, we will work with our Congress at home on additional support."
Kerry cited Egypt's "extreme needs" and Morsi's "assurances that he plans to complete the IMF process" when he told the president that the U.S. would provide $190 million of a long-term $450 million pledge "in a good-faith effort to spur reform and help the Egyptian people at this difficult time."
Separately, the top U.S. diplomat announced $60 million for a new fund for "direct support of key engines of democratic change," including Egypt's entrepreneurs and its young people. Kerry held out the prospect of U.S. assistance to this fund climbing to $300 million over time.
Recapping his meetings with political figures, business leaders and representatives of outside groups, Kerry said he heard of their "deep concern about the political course of their country, the need to strengthen human rights protections, justice and the rule of law, and their fundamental anxiety about the economic future of Egypt."
Those issues came up in "a very candid and constructive manner" during Kerry's talks with Morsi.
"It is clear that more hard work and compromise will be required to restore unity, political stability and economic health to Egypt," Kerry said.
Syria and Iran also came up, according to officials.
With parliamentary elections in April approaching and liberal and secular opponents of Morsi's Muslim Brotherhood saying they will boycott, Kerry called the vote "a particularly critical step" in Egypt's democratic transition.
Violent clashes between protesters and security forces have created an environment of insecurity, complicating Egyptian efforts to secure vital international aid.
Officials in the Egyptian presidency said Kerry stressed the need for consensus with the opposition in order to restore confidence in Egypt that it can ride out the crisis. Morsi was reported to have expressed the importance of Egypt's relationship with United States, which is based on "mutual respect," and focused on the importance of the democratic process in building a strong and stable nation.
Kerry made clear that in all his meetings, he conveyed the message that Egyptians who rose up and overthrew Mubarak "did not risk their lives to see that opportunity for a brighter future squandered."
He also told the country's bickering politicians that they must overcome differences to get Egypt's faltering economy back on track and maintain its leadership role in the volatile Middle East.
The U.S. is deeply concerned that continued instability in Egypt will have broader consequences in a region already rocked by unrest.
U.S. officials said Kerry had planned to stress the importance of upholding Egypt's peace agreement with Israel, cracking down on weapons smuggling to extremists in the Gaza Strip and policing the increasingly lawless Sinai Peninsula while continuing to play a positive role in Syria's civil war.
The impact of his message of unity to the opposition coalition seemingly was blunted when only six of the 11 guests invited by the U.S. Embassy turned up for the Saturday session and three of those six said they still intended to boycott the April parliamentary election, according to participants.
Kerry said that the U.S. would not pick sides in Egypt, and he appealed to all sides to come together around human rights, freedom and speech and religious tolerance.
In an apparent nod to the current stalemate in Washington over the U.S. federal budget, Kerry acknowledged after meeting Foreign Minister Kamel Amr that compromise is difficult yet imperative.
"I say with both humility and with a great deal of respect that getting there requires a genuine give-and-take among Egypt's political leaders and civil society groups just as we are continuing to struggle with that in our own country," he said. 'There must be a willingness on all sides to make meaningful compromises on the issues that matter most to all of the Egyptian people."
The opposition accuses Morsi and the Brotherhood of following in the footsteps of Mubarak, failing to carry out reforms and trying to install a more religiously conservative system.
Morsi's administration and the Brotherhood say their foes, who have trailed significantly behind Islamists in all elections since the uprising against Mubarak, are running away from the challenge of the ballot box and are trying to overturn democratic gains.
From Egypt, Kerry headed to Saudi Arabia on Sunday, with later stops in the United Arab Emirates and Qatar, where his focus is expected to be the crisis in Syria
Kerry is set to return to Washington on Wednesday.
___
Associated Press writer Aya Batrawy contributed to this report.
___
Online:
State Department: http://www.state.gov/secretary/travel/2013/205086.htm
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Video: Along Came Jodi, Part 2
Dateline NBC
'Dateline NBC,' the signature broadcast for NBC News in primetime, premiered in 1992. Since then, it has been pioneering a new approach to primetime news programming. The multi-night franchise, supplemented by frequent specials, allows NBC to consistently and comprehensively present the highest-quality reporting, investigative features, breaking news coverage and newsmaker profiles.
Source: http://www.nbcnews.com/id/3032600/vp/51013983#51013983
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