Researchers find controlling element of Huntington's disease

Wednesday, February 27, 2013

Huntington's disease, also known as Huntington's chorea, is a hereditary brain disease causing movement disorders and dementia. In Germany, there are about 8,000 patients affected by Huntington's disease, with several hundred new cases arising every year. The disease usually manifests between the ages of 35 and 50. To date, it is incurable and inevitably leads to death. It is caused by a specific genetic defect: In the patient's DNA, which is the carrier of genetic information, there are multiple copies of a certain motif. "Repeats like this are also found in healthy people. However, in cases of Huntington's disease, these sequences are longer than usual," explains Dr. Sybille Krauss from the DZNE in Bonn.

The long DNA sequences in Huntington's disease lead to changes in a certain protein called "Huntingtin". The DNA is like an archive of blueprints for proteins. Errors in the DNA therefore result in defective proteins. "Huntingtin is essential for the organism's survival. It is a multi-talent which is important for many processes," emphasises Krauss. "If the protein is defective, brain cells may die."

In the spotlight: protein synthesis

In the current study, the scientists around Sybille Krauss and the Mainz-based human geneticist Susann Schweiger took a closer look at a critical stage of protein production ? translation. At this step, a copy of the DNA, the so-called messenger RNA, is processed by the cell's protein factories. In patients with Huntington's disease, the messenger RNA contains an unusually high number of consecutive CAG sequences ? CAG representing the building plan for the amino acid glutamine.

These repetitive sequences have a direct consequence: more glutamine than normal is built into Huntingtin, which is therefore defective. Sybille Krauss and her colleagues have now identified a group of three molecules, which regulate the production of this protein. "We were able to show that this complex binds to the messenger RNA and controls the synthesis of defective Huntingtin," says Krauss. When the scientists reduced the concentration of this so-called MID1 complex in the cell, production of the defective protein declined.

"If we could find a way of influencing this complex, for example with pharmaceuticals, it is quite possible that we could directly affect the production of defective Huntingtin. This kind of treatment would not just treat the symptoms but also the causes of Huntington's disease," says Krauss.

Background:

Three molecules come together

The complex consists of MID1, from which it gets its name, and the proteins PP2Ac and S6K. "Every single one of these proteins is known to be important for translation. We have discovered that in the specific case of Huntington's disease, they together bind to the CAG sequences. This was previously unknown. We also found that binding increases with repeat lengths," says Krauss. "In sequences of normal length, we found only weak binding or none at all."

The Bonn-based molecular biologist and her colleagues investigated the effect of the MID1 complex and the interaction between its components in a series of elaborate laboratory experiments. "This project took several years of research work," says Krauss. Along with biochemical procedures, the scientists used cell cultures and analysed proteins from the brains of mice. The mice's genetic code had been modified in such a way that it contained elongated CAG-repeats as it is typical for Huntington's disease.

From previous studies it was already known that the protein MID1 tends to bind messenger RNAs. The scientists were now able to show that MID1 also attaches to messenger RNAs with excessively long CAG sequences. Furthermore, experiments showed that PP2Ac and S6K also bound the RNA in the presence of MID1. However, if the MID1 was depleted, this binding did not occur. "From this, we can conclude that these three proteins form a molecular complex, which binds to the RNA. MID1 is a key component. It actually seems to keep together its binding partners," Krauss comments on the results of the experiments.

Complex controls protein production

The researchers were also able to prove that the MID1 complex controls the translation of RNA with excessively long CAG sequences. For this, they investigated various cell cultures. The cells produced either normal Huntingtin or ? due to excessively long sequences in their DNA ? a defective version of this protein. The scientists reduced the occurrence of MID1 inside the cells using a procedure known as "knock-down". The elimination of this protein, which is a major part of the MID1 complex, had direct consequences: the production of defective Huntingtin declined. "However, it did not affect the production of normal Huntingtin," emphazises Krauss. "This further proves that the MID1 complex specifically targets RNAs with excessively long CAG sequences."

Highly specific

The Bonn-based molecular biologist sees this specific influence as a chance to treat Huntington's disease: "The MID1 complex is a promising target for therapy. It indicates a possibility to suppress the production of defective Huntingtin only, while not affecting the production of normal Huntingtin. This is of particular significance, because the normal protein is also being produced in the patients' bodies and it is important for the organism."

A suitable active substance has yet to be found, says Krauss. However, the next developments are in sight: "We now want to test potential substances in the laboratory," she says.

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"Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex", Sybille Krau?, Nadine Griesche, Ewa Jastrzebska, Changwei Chen, D?siree Rutschow, Clemens Achm?ller, Stephanie Dorn, Sylvia M. Boesch, Maciej Lalowski, Erich Wanker, Rainer Schneider, Susann Schweiger, Nature Communications, DOI: 10.1038/ncomms2514.

Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html

Thanks to Helmholtz Association of German Research Centres for this article.

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Source: http://www.labspaces.net/127034/Researchers_find_controlling_element_of_Huntington_s_disease

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Lew set to start at Treasury as budget cuts loom

WASHINGTON (AP) ? Jacob Lew is scheduled to be sworn in Thursday as Treasury secretary and will have to hit the ground running.

He is taking over the job just a day before huge automatic government spending cuts are set to take effect. He's likely to be involved with any negotiations to reverse the cuts, and also in budget talks next month to continue funding the government.

The Senate confirmed Lew late Wednesday, affirming President Barack Obama's choice of a budget expert at a time when Congress and the White House are at odds over spending and taxes.

"At this critical time for our economy and our country, there is no one more qualified for this position than Jack," Obama said in a statement issued after the Senate vote. "His reputation as a master of fiscal issues who can work with leaders on both sides of the aisle has already helped him succeed in some of the toughest jobs in Washington."

The vote was 71 to 26 to support the nomination. Voting against Lew's confirmation were 25 Republicans and independent Bernie Sanders of Vermont.

Lew, 57, had most recently served as Obama's chief of staff. He succeeds Timothy Geithner, who completed a tumultuous four-year term in which he helped lead the administration's response to the financial crisis and recession.

Lew began his government service in the 1980s as an aide to House Speaker Tip O'Neill. He brings nearly three decades of government service to the job, including two stints as White House budget director.

Republican Sen. Jeff Sessions of Alabama, who opposed the nomination, said Lew as budget director was the architect of the Obama's administration's failed efforts to get soaring deficits under control.

During his confirmation hearing, Lew signaled no major economic policy changes. He advocated a balanced approach to reducing the long-term budget deficit through spending cuts and additional tax revenue.

He said he would be open to reforms to Medicare, but he didn't spell out any details. Lew also said he would work with the committee on a rewrite of the tax code.

Beyond the budget, Lew is expected to hew closely to the positions Geithner struck on Europe's debt crisis, the U.S. relationship with China and the administration's defense of the Dodd-Frank financial overhaul law that the banking industry has fought to weaken.

Some Republicans voted against Lew because they were not satisfied with his answers about his previous employment with Citigroup, including a brief time when he was chief operating officer for an investment unit in 2008. The unit has been criticized for making risky investments that imploded during the financial crisis. And Lew received a bonus of nearly $1 million in early 2009, a time when Citi was being bailed out by taxpayers.

Lew told the panel that he didn't make decisions about the investments being offered to clients. He said his bonus reflected compensation for his work.

Sen. Charles Grassley, R-Iowa, opposed Lew's nomination. He cited questions about his time at Citi, as well as Lew's compensation while working as chief operating officer at New York University.

"Mr. Lew's eagerness and skill in obtaining bonuses, severance payments, housing allowances and other perks raises concerns about whether he appreciates who pays the bills," Grassley said.

One potential weakness for Lew: His relative inexperience with financial markets and international economic crises ? areas that had played to Geithner's background. Analysts think Lew will keep pressuring Europe to deal aggressively with its budget and debt issues. But they think this will consume less of his time given that Europe's debt crisis now poses less of a threat to the global economy.

On trade, Lew is expected to keep prodding China. The U.S. trade gap with the world's second-largest economy hit another record high last year. No breakthrough is expected, though.

Lew will also need to calm investors who have grown concerned about possible currency wars after Japan's new government sought to lower the value of the yen as a way to boost exports and its weak economy. A weaker yen makes Japanese goods cheaper overseas and foreign goods costlier in Japan.

And Lew will need to defend the Dodd-Frank Act, which overhauled financial regulation after the 2008 crisis. Since the law was passed in 2010, Wall Street has fought to weaken many of its stricter regulations.

He may also need to work on his signature, which starts off with a soft "J'' but is followed by seven loopy scribbles that render it illegible. The Treasury secretary's signature is emblazoned in the lower right corner of U.S. dollar bills of all denominations.

When he announced Lew's nomination, Obama said Lew had promised to work to make one letter legible "in order not to debase our currency."

Source: http://news.yahoo.com/lew-set-start-treasury-budget-cuts-loom-090252492.html

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Healthy Crock Pot Recipes: Low-Calorie Slow-Cooker Meals

By Lynn Andriani

Everyone's favorite kitchen workhorse can do a lot more than short ribs, as these light, bright dinners show. (Slow pizza, anyone?)

• Pizza -- Really!

  Homemade pizza may not initially seem like a classic slow-cooker dish, but Robin Robertson, author of <a href="http://www.barnesandnoble.com/w/fresh-from-the-vegan-slow-cooker-robin-robertson/1113641477" target="_blank"><i>Fresh from the Vegan Slow Cooker</i></a>, says it totally makes sense, since you don't have to worry about burning it, and turning on a Crock-Pot won't make your kitchen hot (but cranking the oven up to 500 degrees sure will). This thick and chewy pizza is a light version of the deep-dish personal pan ones served in restaurants, with much less oil (just a tablespoon) and no butter. <b>Get the recipe: <a href="http://www.oprah.com/food/Puttanesca-Pizza-Recipe" target="_blank">Puttanesca Pizza</a></b>

• The New Greek Supper

  We love the classic Greek dinner of grilled or roasted meat wrapped up in a pita as much as anyone, but we've fallen hard for this vegetarian dish. Michele Scicolone, author of <a href="http://www.amazon.com/Mediterranean-Slow-Cooker-Michele-Scicolone/dp/0547744455" target="_blank"><i>The Mediterranean Slow Cooker</i></a>, simmers a big pot of white beans in a savory tomato sauce and then sprinkles it with tangy feta cheese. It takes about eight hours to cook, so you can start it in the morning and forget about it until dinnertime. <b>Get the recipe: <a href="http://www.oprah.com/food/Giant-Beans-in-Tomato-Sauce-Recipe" target="blank">Giant Beans in Tomato Sauce</a></b>

• The Southern Classic, Lightened Up

  In this recipe from <a href="http://www.barnesandnoble.com/w/fresh-from-the-vegan-slow-cooker-robin-robertson/1113641477" target="_blank"><i>Fresh from the Vegan Slow Cooker</i></a>, quinoa replaces rice and mixes with black-eyed peas to create a new spin on two Southern dishes, dirty rice and hoppin' John (which usually consists of peas, rice and bacon). For an even heartier meal, add some cooked crumbled or chopped vegan or vegetarian sausage just before serving, which adds flavor without tons of extra calories. <b>Get the recipe: <a href="http://www.oprah.com/food/Dirty-John-Quinoa-Recipe" target="_blank">"Dirty John" Quinoa</a></b>

• Salmon ? la You

  While many slow-cooker recipes can take eight hours or more, this is one you can start in the late afternoon and still have ready by 7. It'll take just two hours for a broth made from vinegar, water and a handful of vegetables to become rich and savory, and less than 30 minutes for salmon steaks -- a staple for calorie counters -- to poach. Then, you can use the fish any number of ways, Scicolone says. Serve it plain with some of the cooking broth, chill for seafood salad, or eat hot or cold alongside <a href="http://www.oprah.com/food/Curtis-Stones-Tzatziki-Sauce" target="_blank">tzatziki</a> or <a href="http://www.oprah.com/food/Creative-Pesto-Recipes-Alexandra-Guarnaschelli-Pesto-Recipes" target="_blank">pesto</a>. <b>Get the recipe: <a href="http://www.oprah.com/food/Poached-Salmon-in-Court-Bouillon-Recipe" target="blank">Poached Salmon in Court-Bouillon</a></b>

• The Colorful Antidote To The Winter Blahs

  In Moroccan cuisine, a tagine is a slow-cooked stew braised at a low temperature, traditionally in a cone-shaped tagine pot. You can re-create this steamy environment in a Crock-Pot. This recipe from <a href="http://www.amazon.com/Mediterranean-Slow-Cooker-Michele-Scicolone/dp/0547744455" target="_blank"><i>The Mediterranean Slow Cooker</i></a> -- which includes carrot, rutabaga, butternut squash and apricot -- looks beautiful on the plate and might just be the sweetest way to eat your vegetables. Regular or Israeli couscous (both come in whole wheat varieties) are the perfect accompaniment. <b>Get the recipe: <a href="http://www.oprah.com/food/Golden-Vegetable-Tagine-Recipe" target="_blank">Golden Vegetable Tagine</a></b>

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Source: http://www.huffingtonpost.com/2013/02/26/healthy-crock-pot-recipes-slow-cooker_n_2744167.html

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Stick to These Ways To Ensure An Optimal Exercise Routine ...

Healthy Lifestyles - Continue to keep in conformity having a extensive exercise routine by visualizing 1 fantastic, individual cause to function in the direction of health and fitness. This might be an upcoming marriage ceremony, an impending secondary school reunion, or a friend's wedding ceremony that you understand will likely be attended by somebody that you would like to amaze with a beautifully toned entire body.

Physical fitness demands about three stuff, determination for your desired goals, a enthusiasm to modify your life, as well as a program. Without having a program, it's as well very easy to stop your life-style when issues get challenging. The next information and facts will assist you to in making your plan on the highway to staying in good physical shape.

When selecting a health and fitness center, make a 'shopping list'. Make a list of the things which can be most critical for your needs. Think about the various products they provide, place, value, hrs, trainers, courses, youngster treatment etc. Also, determine whether you can sign up with a calendar month to calendar month foundation, therefore you aren't locked directly into a lasting arrangement when you find that the gym doesn't meet your expectations.

Make exercise a concern in your own life. Publish it on your schedule or include it within your scheduling plan. In case you wait around to accomplish it before you have plenty of time, or whenever you think about it, you are going to not have it accomplished. You must be steady if you want see significant outcomes.

You ought to bear in mind the complete effect of the workout routine emanates from each its power and it is duration. If you require better results but are not able to modify one of these aspects, increase the other one to compensate. No extra time? Exercise tougher. No room within your system for doing work trickier? Work out lengthier.

Training often and frequently. Train at least two to four times weekly, however, a regular workouts are greater. Your consultations don't must be long. 15 to twenty minutes per day is good. 1 hour is utmost. The standard and regularity of your coaching tend to be more essential than quantity.

Strength training needs to be a large portion of any fitness program. Bodyweight lifting will help construct muscular mass and lean muscle burns more kilocalories then excess fat, so losing weight is going to be a less strenuous objective to accomplish. Pounds lifting likewise helps to create energy and is also a improve to the metabolic processes.

Source: http://healthy-ls.blogspot.com/2013/02/stick-to-these-ways-to-ensure-optimal.html

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Non-brittle glass possible: In probing mysteries of glass, researchers find a key to toughness

Feb. 26, 2013 ? In a paper published online Feb. 26 in the journal Nature Communications, a Yale University team and collaborators propose a way of predicting whether a given glass will be brittle or ductile -- a desirable property typically associated with metals like steel or aluminum -- and assert that any glass could have either quality.

Ductility refers to a material's plasticity, or its ability to change shape without breaking.

"Most of us think of glasses as brittle, but our finding shows that any glass can be made ductile or brittle," said Jan Schroers, a professor of mechanical engineering and materials science at Yale, who led the research with Golden Kumar, a professor at Texas Tech University. "We identified a special temperature that tells you whether you form a ductile or brittle glass."

The key to forming a ductile glass, they said, is cooling it fast. Exactly how fast depends on the nature of the specific glass.

Focusing on a new group of glasses known as bulk metallic glasses (BMGs) -- metal alloys, or blends, that can be extremely pliable yet also as strong as steel -- researchers studied the effect of a so-called critical fictive temperature (CFT) on the glasses' mechanical properties at room temperature.

When forming from liquid, there is a temperature at which glass becomes too viscous for reconfiguration and freezes. This temperature is called the glass transition temperature. Based on experiments with three representative bulk metallic glasses, the researchers said there is also, for each distinct alloy, a critical temperature that determines the brittleness or plasticity of the glass. This is the CFT.

Researchers said it's possible to categorize glasses in two groups -- those that will be brittle because in liquid form their CFT is above the glass transition temperature, and those that will be ductile, because in liquid form their CFT is below the glass transition temperature.

They previously thought a liquid's chemical composition alone would determine whether a glass would be brittle or ductile.

"That's not the case," Schroers said. "We can make any glass theoretically ductile or brittle. And it is the critical fictive temperature which determines how experimentally difficult it is to make a ductile glass. That is the major contribution of this work."

The finding applies theoretically to all glasses, not metallic glasses only, he said.

"A glass can have completely different properties depending on the rate at which you cool it," Schroers said. "If you cool it fast, it is very ductile, and if you cool it slow it?s very brittle. We anticipate that our finding will contribute to the design of ductile glasses, and in general contribute to a deeper understanding of glass formation."

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The above story is reprinted from materials provided by Yale University. The original article was written by Eric Gershon.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Golden Kumar, Pascal Neibecker, Yan Hui Liu, Jan Schroers. Critical fictive temperature for plasticity in metallic glasses. Nature Communications, 2013; 4: 1536 DOI: 10.1038/ncomms2546

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/IAkXMDL7waM/130226114023.htm

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Futurity.org ? In Sudan, efforts to erase breast cancer stigma

In some rural African communities, where men are allowed more than one wife, women with breast cancer have a great fear of being disfigured by surgery and losing a husband and support for their children, so they will often hide the disease and not seek treatment until they are in severe pain. (Credit: United Nations Photo/Flickr)

PURDUE (US) ? A new program that uses local volunteers helps overcome the shame and social barriers faced by women in sub-Saharan Africa that prevent early screening for breast cancer.

In rural Sudan, lack of resources, social stigmatization, and religious beliefs can keep women from seeking help for breast cancer, the most commonly diagnosed cancer and the second leading cause of death in women.

?Patients in Africa often present with late-stage breast cancer that has spread to other organs and is very difficult to treat,? says Sulma Mohammed, an associate professor of cancer biology at Purdue University.

?There is a strong social stigma associated with the disease and a great lack of awareness of the importance of early detection. The same approaches that are successful in the United States don?t work in these rural areas. We need an approach that could overcome the barriers preventing these women from seeking help because thousands of women are dying needlessly.?

Mohammed, who is from Sudan, says the social barriers to screening programs and early detection are especially difficult to overcome. ?The stigma surrounding cancer is so great that people hide the disease from their family and friends and will not seek treatment until they are in severe pain,? she says.

?Women in rural areas where men are allowed more than one wife have a great fear of being disfigured by surgery and losing a husband and support for their children.?

In addition, some African communities are Muslim and women cannot expose their breasts to a male doctor or nurse as part of a screening program.

?We used young female volunteers from the community so that the screenings came from a familiar and trusted person who shares the patient?s social fabric and belief system,? Mohammed says. ?If you are approached by someone you know and trust, you tend to be more relaxed and more forthcoming with any symptoms you may have.?

Researchers first met with village leaders to discuss the effects of cancer on the community and to get approval of the screening program. The leaders then chose candidates for the training, Mohammed says.

Health-care workers provided a five-day intensive training course to female volunteers from selected villages in cancer risk factors, the importance of early detection, and how to examine breasts for abnormalities. The volunteers then went door to door in their village to screen women 18 and older. The volunteers referred women with suspected breast cancer to the district hospital for diagnosis. The program also included a cancer awareness campaign for both men and women.

Between Jan. 1, 2010, and Oct. 15, 2012, in Keremet County 10,309 women were screened, which is roughly 70 percent of the female population. Breast abnormalities were found in 138 women, who were then referred to the district hospital. Seventeen of the women referred were diagnosed with various stages of breast cancer. After treatment, 12 were reported to be disease-free and had good prognosis as of the most recent follow-up.

In contrast, in the socially and economically similar villages of Abugota County, where no screenings took place, four women reported to a health center and three were diagnosed with advanced breast cancer and had poor prognosis.

?Despite the small size of the screened population, 12 women were diagnosed with breast cancer and treated that otherwise may not have been seen until their cancer progressed into an advanced stage,? Mohammed says. ?We hope that one day such screening programs will be common throughout rural Africa.?

In addition to the social barriers, sub-Saharan African countries like Sudan do not have the infrastructure, resources, equipment, or trained personnel to follow successful initiatives used in the United States and other high-income countries.

Mammography-based screening, which is standard in many countries, is not a realistic screening model for sub-Saharan Africa, Mohammed says.

?For the time being, let?s forget looking deeper through mammography and start by catching the stuff we can see and feel,? she says. ?Awareness campaigns and self-examination are cheap, easy to implement, and could have a dramatic effect on the survival chances of these women.?

Even if it were feasible, mammography-based screening methods may not have as great an impact in Africa. Mammography-based screening has not been shown to be beneficial to women younger than 40, and breast cancer in African women occurs most often in women 34 to 45 years old.

The Sudan National Cancer Institute-funded study is ongoing, and the team plans to follow the women who took part in the study for at least five years. The group also is working to spread the program to another state in Sudan.

Researchers from the University of Gezira in Sudan participated in the study.

Source: Purdue University

Source: http://www.futurity.org/health-medicine/in-sudan-efforts-to-erase-breast-cancer-stigma/

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CSN: Gio hurt himself playing with his dog

PORT ST. LUCIE, Fla. -- Since arriving in camp two weeks ago, Gio Gonzalez has found himself talking more about off-the-field developments -- his connection to the Biogenesis clinic under investigation, his addition to Team USA's roster for the World Baseball Classic -- than anything having to do with actually pitching a baseball.

Tonight, then, offered Gonzalez the opportunity to return to his comfort zone. He took the mound at Tradition Field for his first start of the year, and all was right with the world again.

Even if he was surprisingly nervous in that moment.

"It's good to get on that mound again and get back at it," the left-hander said. "Especially with the fan support I was getting out there. It's good to hear that fans still support you and still love you. There were butterflies. You get the butterflies again. That's a good thing."

Those butterflies manifested themselves into a somewhat shaky first inning for Gonzalez, who was unable to locate his fastball with much consistency and wound up needing 25 pitches to complete the frame. But a mechanical adjustment between innings helped him keep his front shoulder closed and allowed him to start peppering the strike zone with his mid-90s fastball and allowed him to end his brief evening on a high note: 2 scoreless, hit-less innings against the Mets.

"It's trying to pick up the target and stay back. It's trying to stay closed," he said of his mechanical approach. "Just like a hitter, you want to stay compact and not fly open. That's the same thing as a pitcher. You want to stay compact, stay closed and pick up your target on time."

Gonzalez's trademark curveball had no glitches whatsoever; he fired off a couple of knee-bucklers in the first inning, catching both David Wright and Ike Davis.

"Just a gifted athlete, a gifted pitcher," manager Davey Johnson said. "His fastball runs all over the place. And his curveball is unhittable. He's right where he left off."

The only blemish on Gonzalez's night wasn't from his pitching line but on his forehead, where a large red spot emerged out of nowhere. The lefty's explanation: His dog, a French bulldog named Hollywood, did it.

"She gave me a rug burn," he said. "I hate her. And then I love her. And then I look in her face and I love her again."

Gonzalez was loose and carefree as ever, happy to talk about pitching and his dog for a change instead of the Biogenesis story.

He was especially happy to talk about the positive reaction he got from fans who cheered his name when he took the mound for the first time in what has already been an eventful spring.

"You don't know what the reaction is going to be like out there with the fans, when you're in somebody else's ballpark," Gonzalez said. "But when you got a lot of people showing love and supporting you, I think that means a lot to someone. They appreciate it. And I appreciate it."

Source: http://www.csnwashington.com/baseball-washington-nationals/talk/gonzalez-back-his-comfort-zone-mound

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New clot removal devices show promise for treating stroke patients

Feb. 25, 2013 ? Specialists at Stony Brook Medicine's Cerebrovascular and Stroke Center (CVC) are treating patients with a new generation of blood clot removal devices that show promise in successfully revascularizing stroke patients, including those with large vessel blockages. The Solitaire Flow Restoration Device and the Trevo device, approved by Food and Drug Administration (FDA) in 2012 to treat stroke caused by the sudden obstruction of a brain blood vessel (acute ischemic stroke) showed improved results over a previous standard and first generation clot-removal device in clinical trials.

"We have had excellent outcomes using these new devices," said David Fiorella, M.D., Ph.D., a Professor of Clinical Neurological Surgery and Radiology at Stony Brook University School of Medicine and Co-Director of the CVC. "In acute ischemic stroke, 'time is brain,' and in some cases just minutes matter. Therefore, restoring blood flow in an effective and timely manner is critical to the survival and recovery of stroke patients. These new devices enable us to quickly restore blood flow and retrieve the clot in most patients," said Dr. Fiorella, who has performed some 30 procedures on stroke patients using the new devices.

"These blot clot removal devices are an important new component of our armamentarium against stroke" said Henry Woo, MD, Professor of Neurological Surgery and Radiology and Co-Director of the CVC, who has also used both devices in patient procedures. "Our center provides endovascular treatment for acute stroke 24/7, and by having the latest technologies to remove brain blood clots, and the expertise to perform endovascular procedures, our Center remains on the cutting-edge against this life-threatening condition."

According to the American Stroke Association, stroke remains the fourth leading cause of death and leading cause of adult disability in the United States. On average a stroke occurs every 40 seconds in the country, and someone dies from a stroke every four minutes. These statistics speak to the need to develop more effective drugs, devices, and procedures to treat stroke.

Recent results of clinical trials reported in The New England Journal of Medicine (February 2013) about the use of first generation of blood clot removal devices in the endovascular treatment of acute ischemic stroke revealed that endovascular treatment does not result in better patient outcomes compared to standard drug treatments. Dr. Fiorella contends that while these trial results are important in the search for the best treatment protocols for acute ischemic stroke, the new devices and techniques are markedly better than those used to treat the majority of patients in these trials and may yet prove to be the most effective approach in select patients. Further research trials are being conducted at Stony Brook to investigate the efficacy of these newer, better devices in acute ischemic stroke.

The new devices that Stony Brook cerebrovascular specialists use to perform revascularization are expandable wire-mesh systems that collapse and are delivered into the brain blood vessels through small flexible tubes (microcatheters) which are guided from the groin to the brain. The devices open at the site of the clot, displacing the occlusion and immediately restoring blood flow to the brain. When the devices are withdrawn from the blood vessel, they take the clot with them, allowing the clot to be removed from the blood vessel.

Dr. Fiorella said that while intravenous clot-busting drugs remain a standard part of stroke therapy, endovascular therapies using the new devices are particularly beneficial when treating certain stroke patients.

"In many of the more severe stroke cases where the main arteries of the brain are blocked, intravenous medications are predictably ineffective, failing to open the occluded artery in 70 to 90 percent of the cases. Also, many patients are not eligible for intravenous clot busting medication because of their time of presentation, existing medical conditions, recent surgery, or the medications they take, such as blood thinners," he explained. "In these cases where intravenous medications are ineffective or contraindicated, endovascular treatments using these new devices offer patients the most promise."

"I feel extremely good and am able to do the things I did before my stroke, and that includes taking care of my grandchildren and running road races," said Michael Jezewski, 66, a retiree from Centereach, N.Y., who ran a five kilometer race just two months after his May 2012 stroke. "I believe that Dr. Fiorella's procedure did save my life and contributed greatly to my quick recovery."

Jezewski did not have a history of stroke and collapsed while at doctor's appointment. He was rushed to Stony Brook where Dr. Fiorella performed endovascular treatment with one of the new devices within two hours of Jezewski's sudden collapse. Jezewski's symptoms started with fatigue and no feeling on the right side of his body, and then quickly progressed to paralysis and the inability to speak. Upon awaking from the clot removal procedure, the majority of his symptoms had completely resolved.

When Shelley Broven, 66, of Setauket, N.Y., began to feel dizzy and had a hard time speaking during her husband's 70th birthday party in November 2012, friends called an ambulance from the restaurant. She was rushed to Stony Brook where Dr. Fiorella performed endovascular treatment with a new generation device.

"I don't recall much of what happened after that incident, but within a week I was out of the hospital, beginning rehabilitation, and feeling pretty good," said Broven. "Each week I have more energy and can express myself more clearly," added Broven, whose stroke resulted from a nearly completely blocked carotid artery which sent a blood clot into her brain blood vessels.

About the New Devices

In two separate multicenter clinical trials reported in The Lancet the new devices were compared to a standard first generation clot removal device called the Merci Retriever.

In one published report, the Solitaire device opened blocked arteries in approximately 70 percent of the patients, compared to only 30 percent treated with the previous device. When other therapies were used with Solitaire, the success rate improved to 80 percent. After three months, 58 percent of the patients with the Solitaire device had a good neurological outcome in comparison to 33 percent of those treated with the standard device. In addition, the mortality rates were less than half in those treated with the newer generation device.

Another published report compared the Trevo device with the Merci Retriever. In this trial, the new Trevo device was superior to the older device, with an 86 percent success rate in opening the blocked brain blood vessel. When other therapies were added, the Trevo device success rate was more than 90 percent.

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Story Source:

The above story is reprinted from materials provided by Stony Brook Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Jeffrey L Saver, Reza Jahan, Elad I Levy, Tudor G Jovin, Blaise Baxter, Raul G Nogueira, Wayne Clark, Ronald Budzik, Osama O Zaidat. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. The Lancet, 2012; 380 (9849): 1241 DOI: 10.1016/S0140-6736(12)61384-1

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/PgBIsRaoaLc/130225201809.htm

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Algerian gas plant in terror siege resumes work

ALGIERS, Algeria (AP) ? A gas installation in Algeria that was the site of a terrorist attack last month that left 37 hostages dead partially resumed production Sunday, as the head of the state-owned energy company said he would request armed personnel for energy plants to help prevent future assaults on sites that can be hundreds of miles from the nearest city.

Prime Minister Abdelmalek Sellal started up one of three gas streams at the Ain Amenas site, bringing it up to about 35 percent capacity, according to state radio.

On Jan. 16, a band of al-Qaida affiliated militants attacked the Ain Amenas complex and took dozens of foreign workers hostage. After a four-day standoff, the Algerian army moved in and killed 29 attackers and captured three others. At least 37 hostages, including one Algerian worker, died in the battle.

The Ain Amenas facility is jointly run by BP, Algeria's Sonatrach and Norway's Statoil. Sunday marked the anniversary of Algeria's 1971 nationalization of its oil industry.

Andelhamid Zerguine, head of Sonatrach, said the attack highlighted security weaknesses that the state-owned company hoped to address, particularly the absence of armed personnel to protect installations.

"We carried out a review to try to determine where we could be stronger," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-24-Algeria-Gas%20Plant/id-2894201144c0457aa4da4be90b857c60

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Mouse mothers induce parenting behaviors in fathers with ultra-sonic noises

Feb. 25, 2013 ? Researchers at Japan's Kanazawa University have demonstrated the existence of communicative signalling from female mice that induces male parental behaviour. This research is also described in the February issue of the Kanazawa University Research Bulletin.

Most mammalian parents use communicative signals between the sexes, but it is uncertain whether such signals affect the levels of parental care in fathers. Scientists have long suspected that female mice play a definite role in encouraging paternal relationships between male mice and their pups.

Now, a research team at Kanazawa University led by Haruhiro Higashida in collaboration with scientists across Japan, Russia and the UK, have proven the existence of auditory and olfactory (smell) signals produced by females which actively trigger paternal activity in males.

Higashida and his team conducted a series of experiments with females and males living in established family groups. Pups were removed from the cage for a short time, while one or both parents remained in the nest. The pups were then returned to the cage, away from the nest. Lone females nearly always brought the pups back to the nest, but lone males were less likely to do so.

Most interestingly, the researchers showed that males were much more likely to retrieve pups when they remained with their mate. This behaviour may be related to ultra-sonic noises emitted by females under stress. These sounds are not emitted by males, pups or non-parental females, and they encouraged the males into parental behaviours. The females also released olfactory signals in the form of pheromones, which triggered the same reaction in the males.

Higashida and his team are keen to expand on their results by analyzing neural signalling in the male brain in response to these female communications.

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The above story is reprinted from materials provided by Organization of Frontier Science and Innovation, Kanazawa University, via ResearchSEA.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Hong-Xiang Liu, Olga Lopatina, Chiharu Higashida, Hiroko Fujimoto, Shirin Akther, Alena Inzhutova, Mingkun Liang, Jing Zhong, Takahiro Tsuji, Toru Yoshihara, Kohei Sumi, Mizuho Ishiyama, Wen-Jie Ma, Mitsunori Ozaki, Satoshi Yagitani, Shigeru Yokoyama, Naofumi Mukaida, Takeshi Sakurai, Osamu Hori, Katsuji Yoshioka, Atsushi Hirao, Yukio Kato, Katsuhiko Ishihara, Ichiro Kato, Hiroshi Okamoto, Stanislav M. Cherepanov, Alla B. Salmina, Hirokazu Hirai, Masahide Asano, David A. Brown, Isamu Nagano, Haruhiro Higashida. Displays of paternal mouse pup retrieval following communicative interaction with maternal mates. Nature Communications, 2013; 4: 1346 DOI: 10.1038/ncomms2336

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/j8LjjHkPUsI/130225102141.htm

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'The Avengers' & The Oscars: Cast Of Hit Movie Reunites At Academy Awards

Just like the superheroes they played in the movie, Mark Ruffalo, Chris Evans, Robert Downey Jr., Jeremy Renner and Samuel L. Jackson all huddled together back stage to get a plan together and of course joke around.

Downey suggested the stars of "The Avengers" bow as they headed onstage to make Oscar presentations. Or perhaps curtsy.

When a show worker asked Jackson to stand still so he could be wired with a microphone, the actor faced a backstage wall and pretended he was being frisked by police.

To pass the time, the superheroes watched Melissa McCarthy and Paul Rudd from a backstage monitor.

Suddenly Ruffalo asked, "Did we miss our cue?"

"You want to go out there with them?" asked Jackson.

After presenting two awards, the actors returned backstage, where Downey quipped, "Avengers disassemble."

_ Sandy Coehn ? http://www.twitter.com/apsandy

___

EDITOR'S NOTE ? Show Bits brings you the 85th annual Academy Awards in Los Angeles through the eyes of Associated Press journalists. Follow them on Twitter where available with the handles listed after each item.

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Source: http://www.huffingtonpost.com/2013/02/25/the-avengers-the-oscars-academy-awards_n_2756934.html

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Cyprus votes for president as clock ticks on bailout deal

NICOSIA (Reuters) - Cypriots started voting in a runoff on Sunday to elect a president who must clinch a bailout deal for the island nation to avoid a financial meltdown that would revive the euro zone crisis.

Conservative leader Nicos Anastasiades, who favors hammering out a quick deal with foreign lenders, is favored to win against Communist-backed rival Stavros Malas, who is more wary of the austerity terms accompanying any rescue.

Financial markets are hoping for an Anastasiades victory that speeds up a joint rescue by the European Union and International Monetary Fund before the island runs out of cash and derails fragile confidence returning to the euro zone.

The 66-year-old lawyer took more than 45 percent of the vote in last Sunday's first round, easily beating Malas who took 27 percent.

The winner takes the reins of a nation ravaged by its worst economic crisis in four decades, with unemployment at a record high of 15 percent. Pay cuts and tax hikes in preparation for a bailout have further soured the normally sunny national mood.

Newspaper headlines reflected the grim outlook, warning of an uphill climb for the new president. One described it as walking towards "Calvary", the location where, according to Christian scripture, Jesus Christ was crucified.

"He will be plunged straight into the deep end, and failure is not an option," the Simerini daily wrote. Phileleftheros, another daily, said: "Its a long road ahead, and insight and vision is needed."

Like candidates, newspapers also called on people to vote. Fewer voters were expected to show up at the polls than on February 17 after the third-placed candidate refused to back either contender in the runoff, boosting Anastasiades's chances.

"Whatever happens in this vote, the day after is going to be very difficult for Cyprus," said Demetris Charalambous, a 56-year-old convenience store owner. "People are really depressed. Business is bad, we are at risk of shutting down."

Prospects for a quick bailout that revives the sinking Cypriot economy - which the EU says will shrink a worse than expected 3.5 percent this year - have been equally grim.

Talks to rescue Nicosia have dragged on eight months since it first sought help, after a Greek sovereign debt restructuring saddled its banks with losses. It is expected to need up to 17 billion euros in aid - worth the size of its entire economy.

Virtually all rescue options - from a bailout loan to a debt writedown or slapping losses on bank depositors - are proving unfeasible because they push Cypriot debt up to unmanageable levels or risk hurting investor sentiment elsewhere in the bloc.

German misgivings about the nation's commitment to fighting money laundering and strong financial ties with Russia have further complicated the negotiations.

END UNCERTAINTY

Longstanding anger over the island's 40-year-old division into the Greek-speaking south and Turkish north has been relegated to a distant second as an election issue this year, with both candidates vying to portray himself as the right man to lead the country out of its financial quagmire.

"We must end the uncertainty and give Cyprus back its lost international credibility and its prestige in Europe," Anastasiades said as he ended his campaign.

A heavy smoker known for his no-nonsense style, Anastasiades is widely respected but suffered political humiliation nine years ago when he supported a United Nations blueprint to reunify the island that was later rejected by the public.

He has suggested the island may even need a bridge loan to tide it over until a rescue is nailed down.

His younger rival Malas is handicapped by the support of the incumbent Communists who are perceived as having mismanaged the economic crisis and a munitions blast in 2011.

Still, he is expected to get a boost from his pledges to drive a hard bargain with lenders and anti-austerity rhetoric that resonates with many Cypriots struggling to make ends meet.

"I want to see someone worthy win, who will cut out cronyism and be decisive about the problems we have," said George Nearchou, 58, an unemployed electrician.

"I am however very worried about austerity, people are very angry. I see a popular uprising."

(Writing by Deepa Babington; Editing by Stephen Powell and Jackie Frank)

Source: http://news.yahoo.com/cyprus-votes-president-clock-ticks-bailout-deal-000647202.html

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Ex-Kent-Meridian teacher, coach receives five-day jail sentence for sex crime

By STEVE HUNTER
Kent Reporter Courts, government reporter
February 22, 2013 ? 5:32 PM

A former Kent-Meridian High School teacher and track coach received a five-day jail sentence Friday in King County Superior Court for communication with a minor for immoral purposes.

After the sentencing at the Norm Maleng Regional Justice Center in Kent, King County corrections officers handcuffed Ernie Ammons, 37, of Black Diamond, and escorted him out of the courtroom and to the county jail. Ammons had been free on bail since his arrest in December 2011.

Judge Lori K. Smith also sentenced Ammons to 40 hours of community service and 24 months of probation as well as ordered that he have no contact with the victim, that he must pay restitution to the victim and that he have no contact with minors except under supervision of an adult with knowledge of his registered sex offender status and with the approval of a sex offender treatment provider.

Ammons pleaded guilty to the charge Feb. 1 in exchange for a lighter sentence. He could have been sentenced up to one year in jail and fined $5,000. He must register as a sex offender.

"It's been a very trying year for me and my family," Ammons said in a brief statement to the judge. "I take responsibility for my actions. I will move forward from this. I apologize to everybody I respect, especially my family and the victim."

Prosecutors said Ammons sent sexually explicit text messages to a 16-year-old Kent-Meridian girl from June 27, 2011 to Nov. 6, 2011. Ammons taught health and physical education at the school. He also coached boys and girls track and cross country for the Royals.

The Kent School District placed Ammons on paid administrative leave in November 2011 when the allegations first came to the district's attention. He resigned from the district in January 2012. He initially pleaded not guilty to the charge in December 2011.

"Mr. Ammons lost a lot here," defense attorney Brad Meryhew said to the judge. "In the process he never made any excuses, never tried to blame anybody else - always taking responsibility."

Ammons met with a psychologist last fall to figure out a treatment plan and will participate in a sex offender treatment program with a mental health counselor in Pierce County.

"I think the next phase for him is to find a way to reach out and get support - and group (meetings) is a great way to do that - you meet a lot of other people to get that kind of support," Meryhew said. "I'm confident that Ernie will recover from this and live a good life."

Smith said she received several letters in support of Ammons.

"The court is going to follow the agreed recommendation, given all of the circumstances it seems appropriate," Smith said. "The court is hopeful that the treatment will continue and recommendations will be followed."

Smith ordered a sentence of 12 months of supervised probation and 12 months unsupervised if Ammons meets the sex offender treatment plan.

Ammons signed the following guilty statement on Feb. 1:

"On or about a time between June 27, 2011 and Nov. 6, 2011 in King County, I did communicate with (the 16-year-old girl), a person I believed to be a minor, for immoral purposes of a sexual nature," Ammons wrote in a court statement.

Ammons led the Kent-Meridian boys track team to its first state track title in spring 2011 when the Royals captured the Class 4A meet. He coached track and field at Kent-Meridian for eight years. He led the boys track team to a second-place trophy at state in 2009.

Ammons taught health and physical education at Kent-Meridian. His classes in 2011 included health and weight training. The district hired Ammons in 2004.

During a series of text messages with the girl, Ammons asked the girl to meet him for sex in the school's weight room before school.

The case came to the attention of school officials in early November 2011 when a student at another school who knew the 16-year-old girl contacted Kent-Meridian Principal Wade Barringer about inappropriate conversations between a health teacher at the school and a student. The teacher was later identified as Ammons.

Barringer talked to Ammons about the allegations, according to court documents. Ammons told Barringer the phone contacts with the student started on Facebook and the contact continued via text messaging.

Ammons told Barringer that he had exchanged text messages with the girl and they talked about exchanging money for sex. Ammons said he never intended to act on the suggestion, but he was afraid to stop texting the girl out of fear that she would expose him.

School officials contacted Kent Police Nov. 8, 2011 about the allegations and the police investigation started. Detectives gathered cellphone records and emails that showed Ammons had contacted the girl. Detectives found as many as 46 calls between the girl's phone and Ammons' phone from June 27 to Oct. 24. Several more text exchanges occurred after Oct. 24.

Ammons has volunteered as an assistant Green River Community College men's and women's cross country and track coach in Auburn since 2009.

Ammons was the second South Puget Sound League coach charged with a sex crime by county prosecutors in November 2011.

A jury found Daniel Gregory Lum-Lung, who coached girls volleyball at Mount Rainier High School in Des Moines, guilty of third-degree attempted rape of a child and communication with a minor for immoral purposes in connection with a 15-year-old girl he met in October 2011 at Kent's Lake Meridian Park. He is scheduled to be sentenced Friday, March 1 before King County Superior Court Judge Andrea Darvas.

Contact Kent Reporter Courts, government reporter Steve Hunter at shunter@kentreporter.com or 253-872-6600, ext. 5052.

Source: http://feedproxy.google.com/~r/pnwlocalnewsnews/~3/54fUXgJKryY/192609981.html

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my recomendation

When I was a newcomer I was able to find my way around by looking at the main forum pages. I was slightly confused by the OOC and Roleplay Academy, but after I got a hello with some advice in the Welcome Desk, it all fell into place pretty quickly. I haven't been a member very long, so I can still remember what my first day was like. I was kind of nervous to explore the first couple of days, but when I needed a gentle push in the right direction, the mods were there to give me one. I can see how a site as big and busy as this might be intimidating when you first start out, but I can't really see them being able to improve it that much. Plus if you ever feel lost, there's guides, other members and scholars, mods and other staff that are eager to help if you just ask. I don't mean to be rude or insensitive to your plight, but I do wish to express that in my experience, if someone is willing to look for the answer to their problem on this site, they'll find it.

If you find anything I've said here to be wrong, I would be more than willing to hear an explanation of your side of it.

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/QlLIhSn5l68/viewtopic.php

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STATE PROPERTY: Another Sale Of A Taxpayer-Backed Business To China?

Republican senators complained Wednesday that U.S. taxpayer dollars could end up boosting the Chinese economy, following reports that a Chinese firm is leading the pack of companies bidding for a majority stake in government-backed Fisker Automotive.

The troubled California-based electric car maker, which was backed by U.S. taxpayers to the tune of nearly $530 million, for months has been looking for a financial partner. Reuters reported earlier this week that China?s Zhejiang Geely Holding Group is favored to take over, though Fisker is also reportedly weighing a bid from another Chinese auto maker.

The development comes after Fisker?s main battery supplier ? U.S. government-backed A123 Systems ? was recently purchased by a separate Chinese firm.

Sens. John Thune, R-S.D., and Chuck Grassley, R-Iowa, voiced concern Wednesday that Chinese companies are benefiting from U.S. taxpayers? investment.

?Obama?s green energy investments appear to be nothing more than venture capital for eventual Chinese acquisitions,? Thune said in a statement. ?After stimulus-funded A123 was just acquired by a Chinese-based company, it?s troubling to see that yet another struggling taxpayer-backed company might be purchased under duress by a Chinese company.?

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Source: http://www.secretsofthefed.com/state-property-another-sale-of-a-taxpayer-backed-business-to-china/

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Warriors rally past Spurs 107-101 in OT

Golden State Warriors' Draymond Green celebrates after scoring against the San Antonio Spurs during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. (AP Photo/Ben Margot)

Golden State Warriors' Draymond Green celebrates after scoring against the San Antonio Spurs during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. (AP Photo/Ben Margot)

San Antonio Spur's Manu Ginobli (20) goes to the basket next to Golden State Warriors' Carl Landry during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. (AP Photo/Ben Margot)

San Antonio Spurs' Manu Ginobili, right, drives the ball against Golden State Warriors' Stephen Curry (30) during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. At left is Spurs' Tiago Splitter (22). (AP Photo/Ben Margot)

Golden State Warriors' Harrison Barnes (40) drives the ball past San Antonio Spurs' Gary Neal during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. (AP Photo/Ben Margot)

San Antonio Spurs' Nando De Colo (25) lays up a shot against Golden State Warriors' Carl Landry during the first half of an NBA basketball game Friday, Feb. 22, 2013, in Oakland, Calif. (AP Photo/Ben Margot)

OAKLAND, Calif. (AP) ? Jarrett Jack had 30 points and 10 rebounds, David Lee added 25 points and 22 boards, and the Golden State Warriors rallied past the San Antonio Spurs 107-101 in overtime Friday night to snap a 16-game losing streak in the series.

Stephen Curry finished with 18 points and six assists to carry the short-sleeve-wearing Warriors from 13 points down in the fourth quarter. Golden State, also playing without center Andrew Bogut, hadn't won against San Antonio since another overtime game at home ? all the way back on Jan. 7, 2008.

Danny Green scored 20 points and Tim Duncan had 19 points and 18 rebounds for the NBA-leading Spurs, who had won five straight and 16 of 17 overall. San Antonio fell to 6-2 on its rodeo trip, which ends Sunday at Phoenix.

The Spurs seemed to take control between the third and fourth quarters, breaking away from a tie game with 13 straight points behind Manu Ginobili and Tony Parker. Both finished with 18 points, and both disappeared late.

The teams traded baskets for the final 6 minutes of regulation.

Lee's driving layup put the Warriors ahead 90-89 with a little more than a minute to play in the fourth. That lead lasted only a few seconds, with Green banking a floater off the glass.

Curry came out of a timeout slashing through the lane and tossed a midair pass out to Jack through a crowd of defenders. Jack swished the 3-pointer with 7.3 seconds to play, pumping his right hand and flexing his muscles around midcourt after giving Golden State a 93-91 lead.

The rest of the celebration would have to wait.

Duncan took the inbounds pass on the other end from Ginobili, who knifed through the lane for a quick give-and-go and a tying layup. Jack missed a desperation shot, sending the game to overtime.

The energy remained rampant in the extra period, and so did the highlights. Curry's long bounce pass just skipped past Ginobili and into the hands of Jack, whose reverse layup gave Golden State a 100-98 lead.

Jack followed with another long jumper, freezing Parker off the dribble to put the Warriors ahead by four with 56.5 seconds left. Green hit a 3-pointer before Parker missed a potential go-ahead layup. Lee grabbed the rebound and tossed the ball to Curry, whose two free throws put the Warriors ahead 104-101.

Duncan's errant pass was stolen on the next possession to seal San Antonio's loss. Jack hit a trio of free throws, and the Warriors finally came out on top against the Spurs.

Golden State was without Bogut, who sat out with back spasms and is out indefinitely. The 7-foot center has missed 43 of 55 games this season, most recovering from surgery on his left ankle.

The new-look Warriors still put to rest a staggering 16 straight losses against San Antonio. The Warriors wore their yellow short-sleeved jerseys complete with pinstriped shorts for the first time, and perhaps the look shook off the Spurs.

At the very least, they caused a stir on the court and around social media.

The first half played out in less mesmerizing fashion, with San Antonio setting its typical plodding pace. Both teams took seven-point leads during the first half, and each struggled to create separation.

The intensity finally picked up late in the third quarter when the home team delighted the announced crowd of 19,596 ? Golden State's 16th straight sellout ? with some daring and dazzling efforts, starting with Curry's bank shot after getting knocked down by Duncan to begin a three-point play.

Jack also surprised Parker from behind for a steal, forced a foul and made both free throws. He added a jumper that tied it at 67 before San Antonio regained its rhythm.

Ginobili twisted his way through the lane for a layup and a jumper as the Spurs scored 13 straight, including the first 12 points of the fourth. They went ahead 80-67 on Green's 3-pointer with 8:55 to play.

Golden State answered with its own 13-0 run capped by a 3-pointer from Curry, whose swish came mere feet in front of jubilant owner Joe Lacob sitting courtside. Both waived to the fans roaring to their feet, setting the stage for the frantic finish.

NOTES: Spurs swingman Stephen Jackson dressed but did not play for undisclosed reasons. He played against the Clippers a night earlier, his first game back since his wife had a miscarriage. Jackson had left the team in Chicago on Feb. 11. ... The Warriors are also planning to wear the sleeved jerseys for home games against Houston on March 8 and Chicago on March 15. ... The Spurs have won 28 in a row against the Warriors in San Antonio.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-02-23-BKN-Spurs-Warriors/id-531faeaf59ce4d15abb27b040229fc24

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Former Komen VP to speak at St. John Fisher College

She was caught in the middle of a controversy between the Susan G. Komen Foundation and Planned Parenthood.

On Thursday, you will have a chance to hear from the former senior VP of public policy from the Komen Foundation.

Karen Handel will speak tonight at Saint John Fisher College. She will talk about her experiences with the foundation especially the decision for the organization to part ways with Planned Parenthood. It's a decision she says has had a major negative impact on the Komen Foundation.

You can purchase tickets for the speech for $15 at St. John Fisher College.

Source: http://brighton-pittsford.whec.com/news/news/95306-former-komen-vp-speak-st-john-fisher-college

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Soroco assistant coach Travis Bruggink offers some advice Thursday during the opening round of the s

Photo by Joel Reichenberger |

February 21, 2013

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Soroco assistant coach Travis Bruggink offers some advice Thursday during the opening round of the state wrestling tournament in Denver.

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